WebMar 23, 2024 · Cytogenetically normal acute myeloid leukemia (CN-AML) is a heterogeneous disease with different prognoses. Researches on prognostic biomarkers … WebMechanistically, NEAT1_1 is released from the nucleus into the cytoplasm of AML cells, regulated by transcription factor C/EBPβ and nuclear protein NAP1L1. Cytoplasmic NEAT1_1 interacts with Wnt component DVL2 and E3 ubiquitin ligase Trim56, facilitates Trim56‐mediated DVL2 degradation, and thus suppresses Wnt signaling. Collectively, …
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WebNature Medicine丨卡博替尼和派姆单抗联合用药治疗复发转移型头颈鳞状细胞癌的二期临床试验结果 WebDec 1, 2024 · NEAT1 is a promising biomarker and an ideal therapeutic candidate for immune diseases. • The risk and concern about gene therapy targeting NEAT1 is proposed. (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) has been shown to be involved in the pathogenesis of several diseases. north dakota luxury homes for sale
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WebApr 17, 2024 · The complex enhances the penultimate step in glycolysis, which sustains high proliferation and drives tumourigenesis independent of nuclear paraspeckles. Cytoplasmic NEAT1_1 has also been described as a regulator of stem cell self-renewal in acute myeloid leukaemia (AML) . In contrast to its role in breast cancer, however, … WebNov 17, 2024 · Collectively, the findings show NEAT1_1 is translocated from the nucleus to the cytoplasm and acts as a tumor suppressor in AML. NEAT1 is downregulated in acute … WebCytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling Huiwen Yan, Zhi Wang, Yao Sun, Liangding Hu, Pengcheng Bu . 2 Supplemental Figure 1. NEAT1 is upregulated in differentiated AML cells. how to resize selection in medibang