Irf4 binding motif

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August undefined, 2024

WebDec 16, 2013 · The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-activated B cells, IRF4 controls germinal … WebFeb 26, 2024 · Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a homodimer and, in conjunction with other TFs, as a heterodimer. The choice of homo and heterodimeric/ DNA interactions is a critical a …

Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T …

WebAug 1, 2024 · PU.1 bound to the CNS3 probe even when the IRF4 binding motif was mutated , probably because the remaining Ets motif in the mutated probe can be bound with monomeric PU.1. To clarify whether PU.1 binds to CNS3 by itself in living cells, we evaluated the effect of IRF4 knockdown on the binding degree of PU.1 to the EICE in CNS3 by a ChIP … WebIRF4 is expressed at a lower level than IRF8 in these progenitor cells; however, IRF4 expression appears to be particularly important for the development of M2 macrophages. … raylib fullscreen

IRF4 as an Oncogenic Master Transcription Factor

WebAug 25, 2024 · IRF4 is critical to full T cell activation, metabolic upregulation, and function but binds DNA weakly on its own and depends on interactions with other transcription … WebJul 17, 2015 · The AICE motif directs assembly of IRF4 or IRF8 (601565) with BATF heterodimers and is also used in TH2, B, and dendritic cells. ... (164720) or Ap1 (165160) binding sites with Pu.1 (SPI1; 165170) or Batf (612476). At higher concentrations, Irf4 binding shifted to interferon sequence response elements, and these enriched for genes … WebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to … raylib header

A multimorphic mutation in IRF4 causes human autosomal …

IrF4 directly binds to nedd4 gene. A. ChIP-seq data

WebDec 10, 2024 · IRF4 acts at the two key stages of pre-B cells, negatively regulating pre-B cell expansion and promoting L chain rearrangement and transcription, directly binding to Ig kappa (k) and lambda enhancer. IRF4 was originally discovered as the partner of the Ets transcription factor PU.1 in the immunoglobulin k light chain enhancer [ 5 ]. WebIRF-4 was initially characterized in lymphocytes and was shown to function as both a transcriptional repressor and activator. More recently, IRF-4 expression and function have … raylib for windowsWebIRF4, a member of the interferon regulatory factor (IRF) family, was previously shown to be restricted in the immune system and involved in the differentiation of immune cells. … raylib hello world

"WebSep 2, 2024 · IRF4 and DNA-Binding Motifs IRF4 belongs to the IRF gene family, which encodes basic leucine zipper (bZIP)-type transcription factor proteins. bZIP proteins possess three modular functional regions: dimerization, DNA binding, and transcriptional regulation regions. " - Irf4 binding motif

Irf4 binding motif

The role of IRF-4 in transcriptional regulation - PubMed

WebSep 1, 2006 · The mammalian IRF family comprises nine members: IRF1, IRF2, IRF3, IRF4 (also known as LSIRF, PIP or ICSAT), IRF5, IRF6, IRF7, IRF8 (also known as ICSBP) and IRF9 (also known as ISGF3γ) 4, 5.... WebIRF4 binds to the canonical IFN-stimulated response elements (ISREs) as a homodimer, and it engages erythroblast transformation-specific IRF composite elements (EICEs) and activating protein 1...

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WebDec 18, 2009 · Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo and furthermore revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. WebApr 24, 2024 · Such diverse functions of IRF4 are thought to rely on multiple DNA binding motifs to which IRF4 binds as heterodimers or its homodimer depending on its protein level. 15 IRF4 binds the Ets-IRF composite elements (EICEs) with PU.1, 16 the AP-1-IRF composite elements (AICEs) with AP-1 family such as Batf, 17, 18, 19, 20 and the interferon sequence …

WebMar 14, 2024 · The IRF4 protein acts like a switch that turns on and off some genes involved in the body’s response to infection. In patients with this mutation, the IRF4 protein does not work as it should. Guérin et al. suggest that Whipple’s disease may be caused by specific genetic mutations affecting the immune system in subjects infected by T. whipplei. WebIRF4 IRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. From: The Immune Response, 2006 Related terms: CD4 IRF8 T Cells Plasma Cell Lymphoma Germinal Center Cellular Differentiation Phenotype B Cell Proteome

WebJan 7, 2003 · PU.1 is a hematopoiesis-specific ets family transcription factor expressed in myeloid and B cells (1, 2).PU.1 binds to DNA and recruits a transactivation partner, IFN regulatory factor 4 (IRF4) (), to an adjacent DNA sequence ().Phosphorylation of S148 in the PEST (proline, glutamine, serine, and threonine rich) domain of PU.1 is essential for strong … WebDec 17, 2024 · BATF and IRF4 bind to AP-1-IRF-composite element (AICE) motifs 37, 38, 39, 40, but how BATF and other AP-1 transcription factors regulate IRF4 activity in the eTreg transcriptional program is...

WebMar 19, 2024 · In addition, we analyzed the distribution of DNA binding motifs within ±3 kilobase pairs (kb) from the sites bound by both IRF4 and NF-κB (Figure 2F; supplemental Table 4). As expected, both IRF and NF-κB binding motifs were enriched at the center of transcription factor binding sites.

WebMUM1 / IRF4 is a nuclear marker that is normally expressed in activated B and T cells, plasma cells and melanocytes. Involved in the differentiation of B cells and T cells. Marker … raylib inputWebNational Center for Biotechnology Information simple winter squash recipesWebIRF4 binding to the ISRE motif in the nedd4 gene locus was further confirmed by the conventional ChIP assay, which showed significant enrichment of IRF4 binding at nedd4 gene promoter in... raylib functionsWebOct 10, 2024 · To investigate whether PDGF D has any biological functions independent of its ability to activate β-PDGFR possibly via the CUB domain, three arginine residues in the R 340 R 341 GR 343 motif within the GFD, known to be critical for its binding to β-PDGFR, were mutated to alanines (TM). 26 To purify recombinant GFD-D proteins, the CUB domain ... simple winter paintings easyWeb(a) Motif analysis of IRF4-binding sites based on the 1,338 most significant peaks (P < 10−10); the 100-bp sequences centered on the binding summit were used for analysis; … raylib instancingWebIRF4 is a negative regulator of TLRs and regulates the production of proinflammatory cytokines by macrophages in response to LPS and signals via complexes containing … simple winter table decorationsWebMay 24, 2024 · NFKB1 is enriched in module “cyan” for binding motif, target transcripts as well as the corresponding pathway. In the same module, we noticed another TF, IRF4 (with its binding partner BATF), of which the binding motif and the corresponding pathway (IL-17 signaling) are both significantly enriched. raylib itch